![]() Here is a brief rundown of the history of organoids and how Molecular Devices found itself a spot on the timeline with its extensive organoid research solutions.īefore Stem Cell: Self-organization and Re-aggregation In fact, the foundations of the concept go back to the beginning of the 20th century. Today’s organoid technology is the product of decades of research. Interestingly, the idea of organoids is not new. ![]() Because these cell cultures self-organize into clusters and differentiate into cell types that make up a functional organ, they are much better at mimicking in vivo conditions. Kerry Grens, an author at The Scientist Magazine, named organoids as one of the “advances of the year.” 1 Organoids have already been developed to represent many different parts of the human body, with applications expected to grow over the next few years.ģD organoids are undeniably at the center of disease modeling and drug discovery. Organoids are already being used to understand disease development methods, neoplasia (cancer), they hold important medical and industrial applications (e.g., toxicology), and ultimately, for transplantation. The rising use of organoids is being fueled by rapid development in stem cell derivations and the desire to reduce the use of animal models. ![]() Organoids may be formed from human or animal cells, which may be differentiated cells, stem cells, or a mixture of both. Let's begin with a simple definition of an organoid which refers to a three-dimensional assembly that contains multiple cell types that are arranged with realistic histology, at least at the micro-scale. History of Organoid Research: From Sponge Cells to Functional Organs
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